MSCA-ITN-2014-ETN: Marie Skłodowska- Curie Innovative Training Networks (ITN-ETN)
TOLLerant “Toll-Like Receptot 4 activation and function in diseases: an integrated chemical-biology approach”
Grant agreement nº: 642157
ESR Position in Nanoimmunology: Nanofunctionalisation of TLR4 agonists and antagonists –Platforms for enhanced delivery with multimodal imaging tracking
Applications are invited for a 36 months position as early-stage researcher (ESR) to work on the Marie Skłodowska-Curie Innovative Training Network TOLLerant from May/June 2015.
The research, which will be carried out at CIC biomaGUNE (San Sebastián, Spain), aims to develop biocompatible (PLGA, gold and iron oxide nanoparticles) with synthetically defined sizes and shapes and a payload of new TLR4 agonists and antagonists, designing and conducting experiments to optimize and scale-up synthesis procedures. These nanoparticles will be simultaneously functionalised using selfassembly methods with an organic dye and gamma or positron emitting radionuclides. Some nanoparticles will be further functionalized with additional ligands actively targeting dendritic cell or macrophage-specific receptors. The goal is to modulate and optimize the in vivo activity of the TLR4 ligands, limiting toxicity. Multimodal imaging and tracking will be applied to assess pharmacokinetic properties and biological fate of the nanosystems, and to gain a fundamental understanding of biological and biochemical processes occurring in vitro and in vivo. Relevant publication: Small, 2014, 10, 5054–5067. doi: 10.1002/smll.201401353.
The successful candidate will join the laboratory of Professor Juan C. Mareque-Rivas and participate in the network’s training activities and work placements at the laboratories of the participating academic and industrial teams. Regular meetings and workshops within the EU-funded TOLLerant International Training Network will supplement the training and support provided at CIC biomaGUNE and the University of the Basque Country.
TOLLerant is a EU funded programme which brings together 8 academic and 2 industrial full partners and 3 associated partners. TOLLerant aims to develop a new generation of innovative, TLR4-based therapeutics, to be used as vaccine adjuvants, anti-sepsis agents, and anti-inflammatory agents to treat chronic inflammations (allergy, asthma). The training programme is designed to provide Early Stage Researchers (ESR) with broad competences, experience and skills in the cutting-edge, inter-disciplinary research field of chemical biology related to the molecular mechanisms of innate immunity and inflammation.
Applicants should meet the following eligibility criteria:
– Have a Diploma and/or a Master Degree in chemistry, biology, chemical engineering, biochemical engineering, biotechnology or biomedical engineering.
– Have less than 4 years research experience at the signature of the contract (measured from the time the Master’s degree has been obtained).
– At the time of application you should not have a PhD degree (although applications will be accepted also from candidates enrolled in a PhD and due to defend the thesis in the next few months)
– Not have resided or carried out main activity in Spain for more than 12 months in the last 3 years immediately prior to the reference recruitment date.
– Excellent knowledge of the English language (spoken and written / proficiency level)
The ESR will be contractually employed by CIC biomaGUNE and will be covered under the social security scheme. He or she will receive a Monthly Living Allowance plus a Mobility Allowance compliant with the applicable EC Marie Skłodowska-Curie Actions-ITN general conditions.
Candidates should submit a CV, cover letter and the names and contact details of at least 3 references by e-mail to email@example.com indicating reference nº 312_TOLLerant in the subject. The deadline for application is 01/05/2015
Early stage researcher or 0-4 yrs (Post graduate)
First Stage Researcher (R1)
Is the job funded through the EU Research Framework Programme?
H2020/Marie Curie Actions
Project’s Marie Curie Grant Agreement Number
Job details_TOLLerant (JCMR) CIC_biomaGUNE