Technologiepark 927 Ghent 9052 BE.
Prof. Rudi Beyaert, VIB- Inflammation Research Center
telephone: +32 9 331 37 70
website: Rudi Beyaert Lab
see also: PubMed, ResearchGate, ResearcherID, Linkedin
PhD Student Aurora Holgado
PI: Prof. Rudi Beyaert
Project Title: Characterization of TLR4 modulators in cellular models and in mouse models of sepsis and ashtma.
Objectives: Training in cell and animal models, training in industry.
1) Effect of TLR4 modulators on TLR4-induced signalling and gene expression (in vitro culture of cell lines and primary cells, NF-κB and IRF-3 reporter assays, gene expression analysis by Q-PCR, bioassays, ELISA, Bio-Plex) ; 2) Analysis of the therapeutic effect of TLR4 antagonists in mouse models of sepsis and asthma (mouse handling, asthma model, immunological and histopathological assays). Additional secondments will provide a perspective of current protocols and possible synergies that can be exploited by the ESR for his/her future career.