LRRC8D antibody
Volume : 100 µg
Purification : Immunogen affinity purified
Form : liquid
Purity : 95% as determined by SDS-PAGE
Host : Rabbit
Clonality : polyclonal Ab
Clone ID :
Isotype : IgG
Storage : PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background : Non-essential component of the volume-reg µLated anion channel(VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracell µLar or intracell µLar osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member(LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition(PubMed : 24790029, PubMed : 26824658). LRRC8A and LRRC8D are required for the uptake of the dr µg cisplatin(PubMed : 26530471). Mediates the import of the antibiotic blasticidin-S into the cell(PubMed : 24782309).
Immunogen : leucine rich repeat containing 8 family, member D
Aliases : LRRC5
Observed MW : 98-120 kDa
Uniprot ID : Q7L1W4
Reactivity : Human, Mouse, Rat
Application : ELISA, WB
Recommended dilution : WB : 1 : 500-1 : 2000
Gene ID : 55144
Research Area : Signal Transduction